Descargar CODON EVOLUTION: MECHANISMS AND MODELS Libros Gratis
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  • ISBN: 9780199601165
  • Formato de libro: PDF, Epub, DOCx, TXT
  • Numero de paginas: 515 paginas pages
  • Tamaño del archivo: 12MB
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Sinopsis de CODON EVOLUTION: MECHANISMS AND MODELS de :

Codon-based models of evolution are a relatively new addition to the toolkit of computational biologists, and in recent years remarkable progress has been made i n this area. The study of evolution at the codon level captures information contained in both amino acid and synonymous DNA substitutions. By combining these two types of information, codon analyses are more powerful than those of either amino acid or DNA evolution alone. This is a clear benefit fo r most evolutionary analyses, including phylogenetic reconstruction, detection of selection, ancestral sequence reconstruction, and alignment of coding DNA. Despite the theoretical advantages of codon based models, their relative complexity delayed their widespread use. Only in recent years, when l arge-scale sequencing projects produced sufficient genomic data and computational power increased, did their usage become more common. In Codon Evolution, leading researchers in the field of molecular evolution provide the latest insights from codon-based analyses of genetic sequences. The first pa rt of the book provides comprehensive coverage of the developments of various types of codon substitution models such as parametric and empirical models used in maximum likelihood as well as Bayesian frameworks. Subsequent chapters examine the use of codon models to infer selection and other applic ations of codon models to biological systems. The second part of the book focuses on codon usage bias. Both the underlying mechanisms as well as current methods to analyse codon usage bias are presented.


CODON EVOLUTION: MECHANISMS AND MODELS

Comentarios

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Natashia

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Freeman

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Emil

No puedo recordar la última vez que un libro me tenía tan adicto .

Marielle

EXELENTE no la conocia pero cada dia se aprende algo nuevo

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